The purpose of this study was to explore the relationshipsamong creativity personality trait, well-being, and personal innovation behavior, and to test the mediating effect of well-being on creativity personality trait and personal innovation behavior.The participants in this study were researchers of Taiwan's high-technology industry. The survey method was conducted to collect usable data. This study adopted multiple hierarchical regressionanalysis to examine the relationships among variables.The results of this study indicated that researchers' creativity personality trait had positive impact on their personal innovation behavior and on well-being. Well-being had also mediating effect on creativity personality trait and personal innovation behavior. Finally, the linkage between the theory and the practice of creativity personality trait, personal innovation behavior, and well-being were further discussed in this study.