This study aimed to discuss relationships among parent-child relationship, school life adjustment and life satisfaction of disadvantaged students in junior high school. Taking the information bank of the Taiwan Fund for Children and Families in 2013 as the research sample, we obtained 968 valid samples to be analyzed via secondary database analysis and studied by descriptive statistics, Pearson correlation and multiple regressions. The results are as follows: (1) Relationships among parent-child relationship, school life adjustment and life satisfaction of disadvantaged students in junior high school are moderately correlated. (2) The prediction effect toward their life satisfaction is restricted to the parent-child relationship and school life adjustment of the disadvantaged students in junior high school. Finally, discussions and suggestions for instructional implementation and future study were proposed.