A 50 year-old married male patient with past history of atrial flutter suddenly suffered from consciousness disturbance and could not speak around 8:00 am. The thrombus infarct on the divergence of M1/2 of left middle cerebral artery was noted by contrast enhance computer tomography, and cerebral infarct on the territory of left middle cerebral artery was confirmed by magnet resonance image. Although the consciousness of the patient was alert, the conversation was not available and gesticulated communication was noted. Global aphasia was diagnosed. The ability of speech reverted after combined treatment of Western and Chinese medicine, and discharge was suggested.