The Expression of CAV-1 and MMP-2 in Patients with Psoriasis Vulgaris

尋常型銀屑病患者CAV-1和MMP-2表達的檢測

陳晉廣(Jin-Guang Chen) ； 姜昱(Yu Jiang) ； 賴維(Wei Lai) ； 雷立清(Li-Qing Lei) ； 葉楠(Nan Ye) ； 張豔彩(Yan-Cai Zhang) ； 周穎(Ying Zhou)

《台灣中醫臨床醫學雜誌》 18卷1期 (2012/03) Pp. 42-50

https://doi.org/10.6968/TJCCM.201203.0042

摘要

Objective: To explore the expression of caveolin-1 (CAV-1) and matrix metalloproteinase -2(MMP-2) in patients with psoriasis vulgaris and its clinical significance. Methods: The biopsies were taken from skin lesions in 65 patients with psoriasis vulgaris and the skin of l5 normal controls. The expression of CAV-1 and MMP-2 were detected by the SP immunohistochemical method. Results: The expression level of MMP-2 in psoriasis vulgaris were significantly higher than that in the normal controls (P＜0.01); the expression of CAV-1 in psoriasis vulgaris were lower that in the controls (P＜0.05). CAV-1 was negative associated with MMP-2 in psoriasis vulgaris (r=-0.425, P＜0.01). Conclusion: It was concluded that CAV-1, MMP-2 might play important roles in the occurrence and progression of psoriasis, which suggested that CAV-1 might inhibit secretion of MMP-2. Downregulation of CAV-1 that may serve as an aetiological factor in the development of psoriasis.The overexpression of MMP-2 could be responsible for cell-cell and cell-matrix changes noted in psoriatic epidermis.Further mechanistic investigations are required with the potential that CAV-1/MMP-2 protein may be a novel target for therapy of psoriasis.

關鍵字

銀屑病 ； 免疫 ； 中醫

並列摘要

Objective: To explore the expression of caveolin-1 (CAV-1) and matrix metalloproteinase -2(MMP-2) in patients with psoriasis vulgaris and its clinical significance. Methods: The biopsies were taken from skin lesions in 65 patients with psoriasis vulgaris and the skin of l5 normal controls. The expression of CAV-1 and MMP-2 were detected by the SP immunohistochemical method. Results: The expression level of MMP-2 in psoriasis vulgaris were significantly higher than that in the normal controls (P＜0.01); the expression of CAV-1 in psoriasis vulgaris were lower that in the controls (P＜0.05). CAV-1 was negative associated with MMP-2 in psoriasis vulgaris (r=-0.425, P＜0.01). Conclusion: It was concluded that CAV-1, MMP-2 might play important roles in the occurrence and progression of psoriasis, which suggested that CAV-1 might inhibit secretion of MMP-2. Downregulation of CAV-1 that may serve as an aetiological factor in the development of psoriasis.The overexpression of MMP-2 could be responsible for cell-cell and cell-matrix changes noted in psoriatic epidermis.Further mechanistic investigations are required with the potential that CAV-1/MMP-2 protein may be a novel target for therapy of psoriasis.

並列關鍵字

Caveolin-1 ； Matrix Metalloproteinase-2 ； Psoriasis Vulgaris