Cancer related fatigue (CRF) is the common symptom of cancer when progressing. It is a subjective symptom, but the mechanism is unclear and lack of effective treatment in modem medicine. It has severely effect on the patient's quality of life and biopsychology. Caused by a physical breakdown and chronic fatigue syndrome, Chinese medicine considers CRF is a biological imbalance due to a ”Yin Yan dysfunction” that results in imbalances in Qi, Blood, Yin and Yan, and in function disorder of viscera and diagnoses CRF symptom as debilities and fatigue. The Traditional Chinese Medicine has the advantage over regulation of global organic function; therefore, it may be a useful treatment on the cancer related fatigue in the future.