This is a 62-year-old man with history of type 2 diabetes mellitus and osteosarcoma, status post operation, chemotherapy and radiotherapy. He has been suffered from right lower extremity several wounds healing difficulty nearly a year, and accompanied by a variety of complex factors such as infection, poor circulation, poor nutrition, anemia, and immune dysfunction. We can see multiple wounds with ulceratation, suppuration and some fluid leakage over his right thigh and calf at first. The prescription is based on Buzhongyiqitang and San Zhong Kui Jian Tang. In our case, after taking the medicine, we can see the wound improved significantly. In the treatment of cancer patients, enhance the quality of life and relieve patient’s discomfort are the advantages of Chinese medicine.