Migraine is a chronic disease with repeated mild or severe headaches, usually accompanied by various autonomic nervous system symptoms. Migraine is usually unilateral, and its related symptoms may include nausea, vomiting, more sensitivity to light and sound, and physical activity can aggravate the pain. This case is a 53-year-old retired woman who has had migraines for more than 20 years, accompanied by dizziness, head congestion, shoulder and neck pain, and nausea. The diagnosis was the headache with syndrome of phlegm-turbidity, and the exogenous wind and cold. The prescription was used to deprive the evil wetness and eliminate sputum, and relieve the appearance and dispel the cold. After several months of treatment, her migraine got well improved.