This article is to describe the nursing experience of caring a tongue cancer patient who suffered from the troubles of his symptoms and his spiritual problems. The nursing care period was from May 9th to May 22th in 2008. The data was collected via observation, communication by writing, practical nursing and interaction with the patient, and we found the major nursing problems are the skin integrity, pain, fear, spiritual trouble. During the nursing process, we used the comfortable care skills and palliative nursing concepts in the way of whole-person, the whole journey, family, and team to assist the patient to maintain the need and comfort of his body and mind, and to palliate the fears which were brovught from foul odor and pain of the malignant fungating wound and disease progression. Furthermore, the patient could obtain good care of his body and mind, improve his life quality, reduce his fear of death, and then we also help and accompany the patient to finish his last will.