- 期刊
慢性咽炎中藥臨床療效評估
The Chronic Nasopharyngitis Clinical Curative Effect of Traditional Chinese Medicine Assessing
摘要
慢性咽炎為咽部粘膜、粘膜下及淋巴組織的彌漫性炎症。病因可由病毒感染、細菌感染引起。病源體可直接感染咽部，也可由鄰近組織感染，如鼻腔、鼻竇、甚至齲齒蔓延而來。理化因素刺激，包括煙酒過度、高溫粉塵、有害氣體等。某些全身疾病，如貧血、便秘、下呼吸道慢性炎症、心血管疾病引起的瘀血性改變均可致病。在傳統中醫學中，慢性咽炎約略等同於「慢喉痺」。所謂喉痺即指咽喉腫痛，妨礙吞咽的疾患。類似慢性咽炎，多由腎陰虧損.虛火上炎所致。證見：咽部呈淺紅色.乾燥不適等……。近年來環境的改變、生活習性的不同、職業形態的多元化，讓慢性咽炎的成因與治療更趨複雜與難以捉摸。因此，深入對它的研究具有重要的臨床意義。研究目的：評估經驗方「慢性咽炎清熱散瘀方」及傳統方「清咽利膈湯」的療效，藉由兩方之比較，了解兩方治療慢性咽炎的成效，藉以提供開發新藥方之思維。材料與方法：1．取樣慢性咽炎129例隨機分發及雙盲對照，使用「慢性咽炎清熱散瘀方「及「清咽利膈湯」，以湯劑模式每人每天服藥二次，每次180ml治療八周，以慢性咽炎臨床症狀進行自我症狀評量，用統計模式對療程前後之臨床症狀變化做療效評估及比較。結果：實驗方「慢性咽炎清熱散瘀方」及經方「清咽利膈湯」在治療慢性咽炎均有療效，且實驗方在兩次療程中療效均優於經方。
並列摘要
Chronic nasopharyngitis is a diffuse inflammation which occurs in the pharynx mucous membrane, the hypo mucous membrane and the lymph system. Viruses or bacteria infections can cause chronic nasopharyngitis. Pathogen can infect the pharynx directly, and be infected by abutting areas such as the nasal cavities, the paranasal sinus or from decayed teeth. The physical simulating factors include excessive smoking and drinking, high temperature particulate matters, and toxic gas...etc.. Some systemic diseases can cause chronic nasopharyngitis, for example, anemia, constipation, chronic lower respiratoryitis, and meta blood stasis from cardiovascular diseases. In Chinese medicine system, chronic nasopharyngitis is equal to ”man-hou-bi” somewhat. The ”man-hou-bi” is a disease which the swelling in the pharynx and larynx obstructs swallowing. The chronic syndrome is similar with chronic pharyngitis which is most caused by flaming up of asthenic fire and consumption of kidney Yin. And the chronic syndrome are pink color in the pharynx, dry scorch and uncomfortable…etc. Recently, the causes and treatments of chronic nasopharyngitis become complicative and intangible because of variations in the environment and the life style and diversifications in occupations. Therefore, it is very important for clinic from omprehensive researches for chronic nasopharyngitis. Clinical Trials. Objectives: Evaluating the treatment outcomes for experimental prescription of Experiment prescription” and traditional prescription of ”Traditional prescription”. Through comparison knowing these two medicines' treat outcomes for chronic nasopharyngitis. And the study also can give some new perestroika of developing new medicines. Methods: 129 chronic nasopharyngitis cases were randomly chose and double-blind method was used. ”Experiment prescription” and ”Traditional prescription” were taken 180 ml per time, twice a day for 8 weeks. Self-evaluation forms were used before and after the treatment. Subjects criteria: Include criteria: outpatients more than 20 years old and with symptoms of chronic nasopharyngitis. Eliminate criteria: Younger than 20 years old, Could not finish the treatment on the expecting time, Could not fill out the self-evaluation forms detailed before and after the treatment, Taken other medicines during the treatment, and did not limit diet. Outcomes: Both prescriptions ”Experiment prescription” and ”Traditional prescription” had positive treatment outcome on chronic nasopharyngitis. But experimental prescription ”Experiment prescription” had better treatment outcome than traditional prescription ”Traditional prescription” from experiments.