Spleen is viewed as a functional unit in modern medicine, which is involved with digestive system, immune system, blood system and endocrine system, namely, spleen is a multi system and multi organ's unit. Digestion and absorption are its prime and basic functions. When in dysfunctional status, spleen will show its pathologic clues called Spleen-Qi deficiency syndrome. In recent years, a series of researches about Spleen-Qi deficiency syndrome have been developed. Here summing up those modern medicine developments about Spleen-Qi deficiency syndrome.