Pricking bloodletting therapy is a Chinese medicine external treatment method that uses a specific needle to pierce a specific acupuncture point or a certain part of the body and release a certain amount of blood to prevent and treat diseases. Whether it is widely used in the civil or clinical, it has a significant effect. Pricking bloodletting therapy has the characteristics of simple operation, less side effects, quick effect, time saving and low cost, and has broad clinical development prospects. This article is based on theoretical basis, bloodletting technology, experimental research and clinical research progress of puncture and bloodletting therapy in the past 20 years. The clinical part is literature review summary of the departments of internal medicine, ENT, gynecology, pediatrics, orthopedics, surgery, dermatology, etc.