Nursing is a profession that translates scientific knowledge into clinical practice. However, obstacles remain, including empirical knowledge that affects the effectiveness of practice. This paper describes the experience of a practice change of the replacement of peripheral intravenous catheters (PIVC) from 72 to 96 hours, using the Research-to-Practice Pipeline model to illustrate the barriers and promoting strategies during the seven stages (aware, accepted, applicable, able, acted on, agreed, and adhered to) of knowledge translation. We hope to pass on this experience and strategies to reduce the leakage during knowledge trans¬lation to enhance the quality of health care.