This study intends to demonstrate the key attributes of systemic resilience by the case study of pandemic resilience and regional economic resilience during the COVID-19 pandemic. This study reviewed and provided a holistic theoretical understanding of resilience from diverse theoretical bases, which are understood to be critical for recovering from disruptions and disorder resulted from major exogenous shocks and crises. Before the COVID-19 pandemic, many scholars had already been active in promoting sustainability and resilience science. However, systemic resilience has yet to be considered in the transformation of Library and Information Science research and the role of libraries for sustainable development. Resilience has been viewed as the ability of a system to prepare for threats, absorb impacts, recover and adapt following persistent stress or a disruptive event. Five systemic attributes categorized by this study were found to dominate the interdisciplinary resilience literature. Four case studies were conducted to demonstrate two types of systemic resilience to provide practical suggestions for enhancing systemic resilience. This research shows the importance of systemic resilience in response to crises and shocks as well as the sustainability of national health system and regional economic system.