This study aimed to explore the relationship among international tourist hotel market orientation, organization learning, organizational innovation and organizational climate. Research samples were full-time employees who have worked more than six months in the international tourist hotel in Taiwan. Questionnaire surveys with convenience sampling were applied for data collection. There were 650 questionnaires be distributed to staff, and 501 valid questionnaires were received, with a response rate of 77%. Research results indicated that: (1) market orientation had a significant positive effect on organization learning and organizational innovation. (2) organization learning had a significant positive effect on organizational innovation. (3) organization learning had mediation effect on the relationships between market orientation and organizational innovation. (4) Organizational climate moderated the effect between market orientation and organization learning (5) Organizational climate moderated the effect between organization learning and organizational innovation.