Homosexual has existed for a long time, but society did not understood about homosexual since it is not a mainstream thing. However nowadays the society's sexual attitude has change, nursing staff would have a higher chance to face the homosexual patients in the future. Most of the Nursing staff has less experience on taking care of the homosexual patients; they would have a trouble on medical service because of their own sex orientation. Therefore, through the literature review, we would elaborate on gender determination, introducing homosexuality, the coming out of homosexual, how to face them and how to take a good care of them.