- 期刊
生活中之隱形殺手－骨質疏鬆症之藥物治療
The Invisible Killer in the Life-Drug Therapy of Osteoporosis
摘要
長年來骨質疏鬆症對人類生活品質的威脅已為公認事實，近年來生活形態改變，更使骨質疏鬆症受到重視。其成因主要為骨骼溶蝕及骨骼形成兩大作用不平衡所導致。骨質疏鬆症好發於停經後婦女、65歲以上之男性及使用會導致骨質流失藥物之病患等，這些族群應定期安排骨質密度檢查，以評斷骨質流失狀況，並對於骨質疏鬆患者給予治療。目前治療藥物有抗溶蝕及促進同化作用兩大類，抗溶蝕藥物包括鈣、維生素D、雙磷酸鹽類、選擇性雌激素受體調節劑、抑鈣激素等；而促進同化作用僅有teriparatide。此外，無論年紀或性別，所有族群每天皆應攝取足夠鈣及維生素D，並維持對骨骼健康良好之習慣，才能預防及治療骨質疏鬆症。
並列摘要
Osteoporosis has been a major threat to quality of life for many years, and that leads to an increased risk of fracture. The pathophysiology of osteoporosis is the imbalance of bone resorption and bone formation. Osteoporosis is most common in postmenopausal women, men older than age 65 years, and those with drug-induced bone loss, and they should be assessed for osteoporosis by central dual-energy X-ray absorptiometry. The medications for treating osteoporosis include antiresorptive drugs and anabolic therapy. Antiresorptive drugs include calcium, vitamin D, bisphosphonates, selective estrogen receptor modulator, and calcitonin. Currently teriparatide is the only available medication that increases bone formation. All people, regardless of age and sex, should change to a bone-healthy lifestyle, which emphasizes the adequate intake for calcium and vitamin D, regular exercise, tobacco avoidance, and fall prevention to prevent and treat osteoporosis.
延伸閱讀
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