This study discussed the viewpoints of globalization and Universal Application Principle for joining the World Health Organization (WHO). To practice the International Health Regulation and to reach the maximization of human welfare, Taiwan should take part in the activities of the WHO to prevent the increase of contagious disease worldwide. Due to political interference, Taiwan cannot to be a member of the WHO, and become a loophole of Global Outbreak Alert and Response Network. This paper also briefly stresses the importance of Taiwan medical contribution to the world by way of empirical analysis and international division of labour. Therefore, Taiwan has to cooperate with other developed countries? in order to improve its medical industry, and to connect the bridge for medical aid to the developing countries. Moreover, based on the Universal Application Principle, Taiwan should not exclude front the participation of international affairs, and this principle may transform into the legal protection for Taiwan joining the WHO.