Do Antimuscarinics Affect Voiding Function during the Treatment of Overactive Bladder

The safety and efficacy of antimuscarinics in the treatment of overactive bladder syndrome (OAB) are not well established. A literature survey of basic and clinical publications relevant to the use of antimuscarinics in OAB was carried out using the PubMed database. The results in terms of safety and efficacy from evidence-based clinical trails were specifically emphasized. During the storage phase, acetylcholine may be released from both neuronal and non-neuronal source and directly or indirectly excite afferent nerves in suburothelium and within the detrusor. This mechanism is important in the pathophysiology of OAB and the major target for the antimuscarinic drugs. Under the concept of sensory inhibition, the application of the antimuscarinics is most extensive in the treatment of overactive bladder induced by bladder outlet obstruction and neurogenic detrusor overactivity. The available data may be considered promising and the use of antimuscarinics has been demonstrated to be a quite safe approach to the treatment of OAB. Improvement in the patient's quality of life and lower urinary tract symptoms are indicative of the clinical value of the use of antimuscarinics for the treatment of OAB.

並列關鍵字

bladder ； overactive bladder ； antimuscarinics ； detrusor overactivity

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