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The Treatment of Overactive Bladder Syndrome Refractory to Antimuscarinic Therapy

並列摘要


Overactive bladder syndrome (OAB) is a common and bothersome problem which affects about 17% of the population in western countries. The treatment of OAB IS usually a challenge due to the high incidence of treatment failure and symptom recurrence. This article reviews various treatments of OAB refractory to antimuscarinic therapy. A literature search for reports on the clinical management of refractory OAB and its efficacy and safety was performed and a total of 55 articles were reviewed. Treatments included intravesical installation of vanilloid agents, intravesical botulinum toxin-A (BoNT-A) injections, neuromodulation and surgery (various types of augmentation enterocystoplasty).

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