This article described a nursing experience using Watson's caring theory for an end-stage lung cancer patient in hospitalization. The duration of nursing care by the researcher was between June 9 and June 25, 2010. The case came back home due to disease deterioration and the point of death. The methods of data collection included observation, listening, face-to-face interview, and chart review and totally evaluation. The case's nursing problems included pain, the disability of breathing, and sadness. Based on the Watson's caring theory, the researcher not only reduced the case's discomfort, but established the nurse-patient relationship and life review to reduce the case's sadness. This case report was expected to share the nursing experience to clinical nursing staff for the related disease.