The purpose of this study is to integrate quality management and manufacturing flexibility, collect the related research issues, and to construct the one-to-one relationship between quality management programs, manufacturing flexibility, and quality performance. This study focuses on the Taiwan machine tool manufacturers to use the factor analysis and the path analysis to investigate the relationship model. The results indicate that, with few exceptions, most of quality management programs have positive impact on the three types of flexibility. The relationship between supplier management and new product flexibility was found to be insignificant, and computerization was found to have no impact on volume flexibility. But all three types of flexibility have positive impact on the external quality performance.