The central tenet of moral particularism lies in its opposition to the claim that moral principles play some essential roles in morality. The particularists argue that their tenet can be supported by the holism of reason. In this paper, I will argue that there is no compelling reason to think that the holism of reason can hold in the realm of ethics and that even if the holism of reason holds, it cannot be used to justify moral particularism. Finally, I will advocate a new version of the holism of reason and argue that it will give us a better grasp of the nature of morality.