Taiwan has rich hot spring resources. To experience hot spring and taste gourmet at the hot spring area is a growing prosperity. The main objective of this study is to explore the relationship among food consumption motivation, well-being and food neophilic of tourists at hot spring area. The purposive sampling is adopted in this study. Tourists whose age are 18 years and older and have experienced in the Guanziling hot spring area within the past year are research objects. The results show that food consumption motivation of tourists has positive effect on well-being. The food neophilic has the moderation effect to the relationship between food consumption motivation and well-being. According to the results of the study, specific recommendations for the hot spring hotel industry and related catering industry are made as references for future marketing management.