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Synthesis, Physico-Chemical and Antimicrobial Properties of Co(II), Ni(II), and Cu(II) Mixed-Ligand Complexes of Dimethylglyoxime
並列摘要
The synthesis of non-electrolyte mixed-ligand complexes of the general formula [M(Hdmg)B], where M=Co(II), Ni(II) or Cu(II) Hdmg=dimethylglyoximato monoanion, B=2- aminophenol(2-aph), diethylamine (dea) or malonic acid (MOH) are described. Metal analysis, melting points, solubility, conductivity, IR and UV/Visible electronic spectra were used in determining their physico-chemical properties. The antimicrobial activities of the complexes were tested against ＂Esherichia coli, Staphylococcus aureus, Aspergillus niger＂ and ＂Aspergillus flavus＂. The complexes melted / decomposed at 120-306ºC and, most of them dissolved only in polar solvents. The colours of the complexes are mostly dark - brown or red. The spectral results suggest the binding of Hdmg, 2-amino phenol or malonic acid through the N atom and O atoms respectively to the metal ion In the electronic spectra of the complexes, the absorption bands observed in the UV/Visible region are presumed to be either due to charge transfer or intra-ligand transitions from the ligands or d-d transitions from the metal ions. The complexes showed marked antimicrobial activity against the tested microbes at 10 mg/mL. The possible use of the complexes as chemotherapeutic agents is hereby suggested.
延伸閱讀
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