- 期刊
- OpenAccess
Evaluation of the Effect of Aqueous-ethanolic Stem Bark Extract of Commiphora Africana on Blood Glucose Levels of Alloxan Induced Diabetic Wistar Rats
並列摘要
This study was undertaken to evaluate the hypoglycemic effect of aqueous-ethanolic stem bark extract of Commiphora african on blood glucose levels of alloxan-induced diabetes rats. Three doses of the extract (100, 200 and 400 mg/kg) were administered p. o. There was a significant decreased in the blood glucose levels after 1 day of treatment with the dose of 400 mg/kg. Also after 5 and 7 days of treatment there was a significant decrease in the blood glucose levels with the doses of 200 and 400 mg/kg when compared to control. As regards to the dose of 100 mg/kg there was no any significant decreased in the blood glucose levels when compared to control. The Preliminary phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, steroids and saponins. The median lethal dose (LD50) in rats was calculated to be 3.8078 mg/kg body weight. In conclusion the aqueous ethanolic stem bark extract of Commiphora Africana possess anti-diabetic effect in alloxan- induced in diabetic rats.
延伸閱讀
- Goji, A., Dikko, A., Bakari, A., Mohammed, A., Ezekiel, I., & Tanko, Y. (2009). Effect of Aqueous-ethanolic Stem Bark Extract of Commiphora Africana on Blood Glucose Levels on Normoglycemic Wistar Rats. International Journal of Animal and Veterinary Advances, 1(1), 22-24. https://www.airitilibrary.com/Article/Detail?DocID=20412908-200907-201008160039-201008160039-22-24
- Okpanachi, A., Adelaiye, A., Dikko, A., Kabiru, M., Mohammed, A., & Tanko, Y. (2010). Evaluation of the Effect of Aqueous-methanolic Stem Bark Extract of Acacia polyacantha on Blood Glucose Levels of Alloxan Induced Diabetic Wistar Rats. International Journal of Animal and Veterinary Advances, 2(3), 59-62. https://www.airitilibrary.com/Article/Detail?DocID=20412908-201007-201009060078-201009060078-59-62
- Spencer, C. N., Sunday, J. J., Usunomena, U., Udoka, N., Akintola, A. A., Ehiremen, O. I., & Kingsley, O. (2011). Effects of Aqueous and Ethanolic Extract of ＂Vernonia amygdalina＂ Leaf on the Plasma Lipid Profile and Liver Function Parameters of Normal Rats. Current Research Journal of Biological Sciences, 3(5), 504-508. https://www.airitilibrary.com/Article/Detail?DocID=20410778-201109-201512280013-201512280013-504-508
- Balogun, S. O., Tanayen, J. K., Ajayi, A. M., Ibrahim, A., Ezeonwumelu, J. O. C., Oyewale, A. A., Oloro, O. J., Goji, A. D. T., Kiplagat, D. M., & Adzu, B. (2011). Preliminary Evaluation of Anti-Diarrheal, Ulcer-Protective and Acute Toxicity of Aqueous Ethanolic Stem Bark Extract of Ficus trichopoda in Experimental Rodents. Asian Journal of Medical Sciences, 3(1), 37-42. https://www.airitilibrary.com/Article/Detail?DocID=20408773-201102-201510300008-201510300008-37-42
- Eze, E., Mohammed, A., Musa, K., & Tanko, Y. (2012). Evaluation of Effect of Ethanolic Leaf Extract of Mucuna pruriens on Blood Glucose Levels in Alloxan-Induced Diabetic Wistar Rats. Asian Journal of Medical Sciences, 4(1), 23-28. https://www.airitilibrary.com/Article/Detail?DocID=20408773-201202-201510290012-201510290012-23-28