- 期刊
- OpenAccess
Antidepressant Effects of Noni Fruit and its Active Principals
並列摘要
The antidepressant effects of ＂Morinda citrifolia＂ (noni) fruit extracts were investigated ＂in vitro＂ with the Monoamine Oxidase (MAO) A and B bioassays. The ethyl acetate extract of freeze-dried noni fruit powder inhibited MAO-A and B enzymes 78 and 49%, respectively. A phytochemical study of the most active extract led to the isolation of nine compounds. Among these, three principles including two flavonoids, kaempferol and quercetin, as well as one lignan, (+)-3, 4, 3', 4'-tetrahydro-9, 7'α-epoxylignan-7α, 9'-lactone, were found to be potent MAO-A and B inhibitors. These findings indicate that noni fruit is a natural MAO-A and MAO-B inhibitor, involving a synergistic effect from multiple active components.
延伸閱讀
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