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Assessment of Some Selected Trace Metals in Chronic Myeloid Leukemia Patients in a Tertiary Health Facility in South West Nigeria
並列摘要
Some selected trace metals; Iron (Fe), Copper (Cu), Manganese (Mn), Chromium (Cr), Selenium (Se), Calcium (Ca), Zinc (Zn) and Magnesium (Mg) in Chronic Myeloid Leukemia (CML) patients were assessed. Seventy five (75) leukemic patients and 50 apparently healthy control subjects were evaluated in this study. Hematological parameters were estimated by automation SYSMEX KX-21N and the trace elements analysed using Atomic Absorption Spectrophotometry. There were statistical significant differences between serum Fe, Cu,Mn, Se, Ca, Zn andMg ofleukemic patients and that oftheir respective control subjects (p＜0.05) while there was no significant difference between serum chromium ofleukem ic pat ients and the control subjects (p＞0 .05). Variation also existed between the patients and control value s in the hematological parameters such as: PCV, MCV, MCHC, WBC, platelet etc. The study reveals that serum trace elements are useful indice s of the extent ofthe disease in leukemia patients, their levels are independent ofa non specific acute-phase reaction and restoration of serum trace elements are useful in assessing response to treatment in leukemia patients. Monitoring of the respective trace elements in the CML patients could therefore be an essential part of managing the patients.
延伸閱讀
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