Levels of Parasitaemia and Changes in Some Liver Enzymes among Malarial Infected Patients in Edo-Delta Region of Nigeria

I. Onyesom ； N. Onyemakonor

《Current Research Journal of Biological Sciences》 3卷2期 (2011/03) Pp. 78-81

並列摘要

Hepatic dysfunction is a common complication in malaria and this could be characterized by increase in liver enzyme activities. The activities of some liver enzymes: Serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were assayed in 60 individuals comprising both males and females, age between 10-60 years. Malarial parasite status and densities were also determined and correlated with the enzyme values Thirty (30) individuals presenting with acute uncomplicated falciparum malarial infection were selected as test subjects and 30 sex and age-matched apparently healthy individuals without the infection were included as control group. Malarial parasite count was by the Giemsa stain and the liver enzymes were assayed by standard methods. Results show that there was a positive relationship between the enzyme activities and the level of parasitaemia (p＜0.05). Changes in the AST (33.4±16.4 IU/L), ALT (21.3±14.4 IU/L) and ALP (87.4±25.6 IU/L) activities for the infected subjects were higher compared with their non-infected counterparts (AST: 22.3±7.4 IU/L, ALT: 15.2±5.8 IU/L, ALP: 56.4±16.7 IU/L). Evidence indicates a measure of compromise in hepatic integrity and this bears a positive correlation with the levels of parasitaemia. Post-treatment values should be obtained and compared in order to provide a detailed understanding for improved treatment.

並列關鍵字

ALT ； AST ； hepatic dysfunction ； liver enzymes ； Malaria ； P. falciparum