The Evaluation of Neuraminidase Type 2 Models

The aim of this study is to predict a model with the smallest errors by comparing built homology models using three different methods instead of using just one method. The generated models from building homology models always contain errors. The outcomes with smaller errors are the best models to be used for further study. The combination of three methods resulted in the determination of one model, the model no. 2, which is better than the other constructed models. The DOPE score of this model was -36613.3 which held the 4^(th) place in DOPE score rank and the score from profiles-3D was 195.05 which was the best in the verify score rank. The online protein models assessment PROCHECK results showed that 98.8% residues (without Pro and Gly) of this model are in the most favoured and additional allowed regions. The results show that the three methods used, may help to select a better model to be simulated by considering different perspectives than if we choose a model with only one method perspective.

並列關鍵字

Homology modeling ； influenza ； model assessment ； neuraminidase

國際替代計量

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