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The Protective Effect of Ethanolic Extract of Unripe Pulp of ＂Carica papaya＂ (Pawpaw) Against Potassium Bromate Induced Tissue Damage in Wistar Rats
並列摘要
The protective role of ethanolic extract of unripe pulp of Carica papaya (fruit), against potassiumbromate induced tissue damage in wistar rats was investigated. The animals were grouped into four groups (A,B, C, D) of five rats. Group A was administered 1 mL of 0.25 M sucrose solution. 60mg/kg of Potassium bromate KBrO_3 was administered orally to rats in groups B, C and D. Groups C and D were pretreated with 250 and 500mg/kg of the extracts for fourteen (14) days, respectively. The organ to body-weight ratio, total amino acid, total protein and malondialdeyde (MDA) concentration in the brain, spleen, kidney, liver, and heart were colorimetrically measured as an assessment of the level of tissue damage. All the parameters studied increases significantly in all the tissues of rats group B. There was significant decrease in the organ-to-body weight ratio and total protein level in all the tissues investigated (p＜0.05), when compared with Group B at both doses of the extract. The total protein level of the stomach had a drastic reduction at 500mg/kg. Also, the Amino acid level of investigated tissues decreased significantly, while malondialdeyde levels decreased significantly in a dose dependent manner. These findings suggest that ethanolic extract of unripe pulp of Carica papaya may be protective against KBrO_3 induced tissue damage in Wistar rats.
延伸閱讀
- Josiah, S. J., Nwangwu, S. C. O., Akintola, A. A., Vivian, A., Erifeta, G. O., Asuk, A. A., & Uhunmwamgho, S. E. (2011). Protective Role of Water Extract of Unripe Pulp of Carica papaya (Fruit) Against a Potassium Bromate Induced Tissue Damage in Wistar Rats. British Journal of Pharmacology and Toxicology, 2(4), 205-208. https://www.airitilibrary.com/Article/Detail?DocID=20442467-201110-201507070014-201507070014-205-208
- Addai, Z. R., Abdullah, A., Mutalib, S. A., Musa, K. H., & Douqan, E. M. A. (2013). Antioxidant Activity and Physicochemical Properties of Mature Papaya Fruit (Carica papaya L. cv. Eksotika). Advance Journal of Food Science and Technology, 5(7), 859-865. https://doi.org/10.19026/ajfst.5.3173
- Hamman, W. O., Musa, S. A., Ikyembe, D. T., Umana, U. E., Adelaiye, A. B., Nok, A. J., & Ojo, S. A. (2011). Chronic Oral Administration of Ethanol Extract of ＂Carica papaya＂ Seeds Does not Affect the Histology of the Cauda Epididymis of Adult Male Wistar Rats. Asian Journal of Medical Sciences, 3(5), 192-194. https://www.airitilibrary.com/Article/Detail?DocID=20408773-201110-201510300012-201510300012-192-194
- 林庭筠、許文光、周明燕、張惠如、莊孟蓉、謝昌衛（2022）。Physicochemical and Antioxidant Activity of Polysaccharides from the Different Maturity Carica papaya L. Through Ultrasonic-Assisted Extraction。臺灣農業化學與食品科學，60(1)，22-29。https://doi.org/10.6578/TJACFS.202203_60(1).0003
- Okesina, A. A., Mesole, S. B., Olusakin, J., Mohammed, Y. G., Mohammed, A. A., Buhari, M. O., Ashaolu, J. O., Ezekiel, I., Goji, A. D. T., & Martins, E. A. C. (2012). Antioxidant Effect of ＂Carica papaya＂ on Ethanol Induced Gastric Lesion in Adult Male Wistar Rats. British Journal of Pharmacology and Toxicology, 3(3), 147-150. https://www.airitilibrary.com/Article/Detail?DocID=20442467-201206-201507070028-201507070028-147-150