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Efficacy of Ceftobiprole in Treating of Osteomyelitis Due to Methicillin Resistant ＂Staphylococcus aureusin＂ Rabbits
並列摘要
The present study was carried out to investigate antibacterial activity of ceftobiprole and vancomycin invitro and in-vivo after inducing osteomyelitis in rabbit by administration of Methicillin Resistant Staphylococcus Aureus (MRSA). Part I, evaluation is done in-vitro by using hot plate method for appearance zone of inhibition and Minimum Inhibitory Concentration (MIC) against (MRSA). Antibacterial susceptibility test showed that the ceftobiprole was more effective than vancomycin. Part II, inducing osteomyelitis (40 mg/kg B.W) compared with treated with vancomycin at a dose of (30 mg/kg B.W) subcutaneously for 28 days. Ceftobiprole succeeded to treat osteomyelitis by absence methicillin resistant staphylococcus aureus in the infected rabbits and prevented infection compared with vancomycin and radiographic pictures explained normal bone anatomy and all features of osteomyelitis disappeared These results indicate that ceftobiprole provided effective parenteral treatment of osteomyelit is in this rabbit model.
延伸閱讀
- Ho, M. L. (2011). Universal screening for methicillin-resistant staphylococccus [i.e. staphylococcus] aureus control by hospitals [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200019530
- Chen, C. H., Chen, C. H., Pan, H. W., Yen, C. C., Say, W. C., Chen, W. J., & Shih, C. H. (2002). Injectable Calcium Sulfate as a Bone Substiute In Rabbits. Journal of Orthopaedic Surgery Taiwan, 19(1), 28-31. https://www.airitilibrary.com/Article/Detail?DocID=10116923-200203-19-1-28-31-a
- 康鳳蓮（1994）。Pharmacokinetic study of caffeic acid and its esters in rabbits〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-1704200714395334
- 蔡佩均、陳裕信、康定傑、陳立人（2022）。Establishment of osteoporotic rabbit model by ovariectomy and lower Calcium diet。畜產研究，55(2)，92-100。https://doi.org/10.6991/JTLR.202206_55(2).0002
- Liu, D. D., Yang, C. C. H., Lee, R. P., & Chen, H. I. (2000). Opposition of Rapid Baroreceptor Resetting by Prostanoids in Rabbits. The Chinese Journal of Physiology, 43(1), 15-21. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200003-43-1-15-21-a