- 期刊
- OpenAccess
Antibacterial Activity of ＂Nigella sativa L.＂ Seed Extracts
並列摘要
Most of the bacterial pathogens are resistant to existing synthetic antibacterial agents demanding an increasing effort to seek effective phytochemicals as antibacterial agents against such pathogens. Nigella sativa L. (black cumin) seeds play an important role in folk medicine and some of its major constituents are reported to be pharmacologically active. In this present work, black cumin seed extracts were obtained using supercritical carbon dioxide (SCCO_2) and conventional soxtec extraction using various organic solvents. The antibacterial activities of the extracts were investigated by the agar dilution method against Gram-positive bacteria (Bacillus cereus F 4810 and Staphylococcus aureus FRI 722) and Gram-negative bacteria (Escherichia coli MTCC 108 and Yersinia enterocolitica MTCC 859). SCCO_2-1 (120 bar/40°C) extract showed effective growth inhibition than conventional solvent extracts against all the tested bacteria. Further the antibacterial principle present in the extract was isolated and characterized found to be thymoquinone.
延伸閱讀
- Hajifattahi, F., Salehi, E. M., Taheri, M., Mahboubi, A., & Kamalinejad, M. (2016). Antibacterial Effect of Hydroalcoholic Extract of Punica granatum Linn. Petal on Common Oral Microorganisms. International Journal of Biomaterials, 2016(), 108-113. https://doi.org/10.1155/2016/8098943
- Kumar, D., & Bhat, Z. A. (2012). Anti-anxiety Activity of Methanolic Extracts of Different Parts of Angelica archangelica Linn. Journal of Traditional and Complementary Medicine, 2(3), 235-241. https://www.airitilibrary.com/Article/Detail?DocID=P20190807002-201207-201910230012-201910230012-235-241
- Favaretto, A., Tonial, F., Bertol, C. D., & Basso, S. M. S. (2016). Antimicrobial activity of leaf and root extracts of tough lovegrass. Comunicata Scientiae, 7(4), 420-427. https://doi.org/10.14295/CS.v7i4.1845
- 康志強、王櫻娟、邱淑媛（2009）。Antibacterial and Antimutagenic Properties of Extract from Lily Bulb。臺灣農業化學與食品科學，47(5)，221-227。https://doi.org/10.6578/TJACFS.2009.025
- Ichwan, S. J. A., Ani, I. M. A., Bilal, H. G., Suriyah, W. H., Taher, \., & Ikeda, M. A. (2014). Apoptotic Activities of Thymoquinone, an Active Ingredient of Black Seed (Nigella sativa), in Cervical Cancer Cell Lines. The Chinese Journal of Physiology, 57(5), 249-255. https://doi.org/10.4077/CJP.2014.BAB190