Study of Drug-interactions between Phenytoin and Rosuvastatin in Rats

D.M. Lotfy ； S. H. Mohamed ； M. E. El Sayed ； T. M. Fahim

《British Journal of Pharmacology and Toxicology》 5卷4期 (2014/08) Pp. 136-144

並列摘要

Drug interactions between phenytoin and rosuvastatin may occur when used together in normal rats, so the present study was conducted to investigate the effects of the individual as well as combined drugs were studied in normal rats. Rats were divided into 4 groups namely: normal control, phenytoin (60 mg/kg i.p.), rosuvastatin (1.25 mg/kg i.p.) or combination of both phenytoin and rosuvastatin, respectively. Data of the present work revealed that, phenytoin increased serum total cholesterol. Rosuvastatin didn't affect serum total cholesterol or serum triglycerides. Combination increased serum total cholesterol but it didn't affect serum triglycerides. Phenytoin significantly increased serum LDL-C. Rosuvastatin had no effect on serum HDL-C, serum LDL-C and VLDL-C levels. Combination didn't change serum lipoproteins (HDL-C, LDL-C and VLDL-C). Individual drugs or their combination had no effect on risk factor and atherogenic index. Phenytoin significantly increased serum ALT level. Rosuvastatin had no effect on serum AST and serum ALT levels. Combination significantly increased serum AST level. Phenytoin significantly increased serum MDA level but it had no effects on serum NO level and blood SOD activity. Rosuvastatin significantly increased serum NO level. Combination significantly increased serum NO level, so Combination of phenytoin and rosuvastatin has a good effect on oxidative stress by increasing serum NO level. In conclusion, the results revealed that, there are drug interactions between phenytoin and rosuvastatin. The interactions improve liver functions and lipid peroxidation. A part from the action of the combination on total cholesterol, it improves lipid profile.

並列關鍵字

Antiepileptic ； drug interaction ； lipid profile ； liver functions ； oxidative stress biomarkers ； statins