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Evaluation of Aluminium Toxicity and the Ameliorative Effect of Some Selected Antioxidants on Reproductive Hormones and Organs of Female Wister Rats
並列摘要
This research investigated aluminium (Al) toxicity and the ameliorative effect of some selected antioxidants on reproductive hormones and organs of female Wister rats. Vitamin A (vit A), vitC,vitE, selenium(Se), zinc(Zn) and ginseng with Al was orally administered to the rats at varying doses to determine their ameliorative potential. Forty eight female rats were grouped in eight of six rats each. The groups were treated as follows: Group 1 served as control and was given just rat feed and water. Group 2 was given 200mg/kg body weight of Al. Group 3was given 14.8mg/kg body weight of Zn+200mg/kg body weight of Al, Group 4 was given 100mg/kg body weight of Se+200mg/kg body weight of Al, Group 5 was given 10 mg/kg body weight of Ginseng+200 mg/kg body weight of Al, Group 6 was given100 mg/kg body weight of vitA+200mg/kg body weight of Al, Group 7 was given 100mg/kg body weight of vitC+200mg/kg body weight of Al, Group 8 was given 100mg/kg body weight of vitE+200mg/kg body weight of Al. The rats were treated for 6 weeks. The hormonal and histopathological examinations of the ovaries were determined using standard methods. There was no significant difference (p＞0.05) in serum prolactin (PRL), luteinizing hormone (LH) and follicle stimulating hormone (FSH). The result of progesterone (PROG) assay showed a significant decrease (p＜0.05) in the aluminium fed group when compared to the control. However, progesterone level in groups treated respectively with Al+Se, vitA, C and E showed a significant increase (p＜0.05) while ginseng showed no significant (p＞0.05) ameliorative effect. Photomicrographs showed a marked vacuolation in the stromal cells of the ovary in the Altreated group with no histological changes observed in all the other groups. The study suggests a distortion of the membrane of the ovary leading to a disruption of the endocrine system.
延伸閱讀
- Lin, M. F., Chen, M. L., & Chen, J. S. (1966). Effect of Amino Acid Supplementation on Growth and Some Liver Enzyme Activities of Rats Fed Different Vegetable Protein Diets. The Chinese Journal of Physiology, 19(4), 381-389. https://www.airitilibrary.com/Article/Detail?DocID=03044920-196606-19-4-381-389-a
- Spencer, C. N., Sunday, J. J., Usunomena, U., Udoka, N., Akintola, A. A., Ehiremen, O. I., & Kingsley, O. (2011). Effects of Aqueous and Ethanolic Extract of ＂Vernonia amygdalina＂ Leaf on the Plasma Lipid Profile and Liver Function Parameters of Normal Rats. Current Research Journal of Biological Sciences, 3(5), 504-508. https://www.airitilibrary.com/Article/Detail?DocID=20410778-201109-201512280013-201512280013-504-508
- Buhari, M., S.B, M., Jimmy, O., Okesina, A., & Mohammed, A. (2015). Antioxidant Activities of ＂Allium sativum＂ on some Biochemical parameters following Ethanol Induced Lesion in the Gastric Mucosa of Adult Male Wistar Rats. Current Research Journal of Biological Sciences, 7(3), 43-46. https://www.airitilibrary.com/Article/Detail?DocID=20410778-201507-201509150008-201509150008-43-46
- Mesole, S. B., Olusakin, J., Mohammed, Y. G., & Oyesomi, T. J. (2012). Investigation of Some the Activities of G6PDH and LDH in the Liver of Adult Male Wistar Rats Following the Administration of Aqueous Extract of Ocimum sanctum. Asian Journal of Medical Sciences, 4(5), 170-173. https://www.airitilibrary.com/Article/Detail?DocID=20408773-201210-201510290016-201510290016-170-173
- 洪玉軒（2007）。Study on the efficacy of soy-isoflavones, vitamin E and vitamin D on obesity and biological activities in ovariectomized rats〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-1608200712011800