Pasteurella multocida is a rare cause of peritonitis and empyema. We report here a case of peritonitis concomitant with empyema due to P. multocida. This 68-year-old male farmer and pet-dog owner with a history of liver cirrhosis and chronic obstructive pulmonary disease was admitted to the hospital due to bilateral legs edema for 3 months and decreased urine output for 7 days. Sepsis and acute respiratory failure developed during hospitalization. P. multocida was isolated from the cultures of ascites and pleural effusion. He was then discharged uneventfully after antibiotic treatment with imipenem / cilastatin, amoxicillin / clavulanate and close thoracentesis.