The Serogroup and Antibiotic Susceptibility in Salmonella That Was Isolated from the Children in a Hospital

某醫院兒童沙門氏桿菌感染之探討研究

洪宜君(Yi-Chun Hung) ； 高佳慧(Chia-Hui Kao)

《童綜合醫學雜誌》 5卷2期 (2011/12) Pp. 57-60

https://doi.org/10.29838/TMJ.201112.0002

摘要

沙門氏桿菌之感染是個相當古老但仍對人類肆虐的疾病，如大家所熟知的傷寒即是它們的傑作之一。沙門氏桿菌腸胃炎更是嬰幼兒細菌性腸胃炎最常見的病因之一。近年來由於抗生素普遍的使用，臺灣沙門氏桿菌之抗藥性也相當嚴重，造成病患治療上的困難。所以，如何適當選擇抗生素成為醫師面對病患時很重要的一個課題。本研究以回溯性病例收集分析本院96年1月1日至98年12月31日間因急性腸胃炎住院的病患，以電腦將96-98年因腸胃炎住院且確定為沙門氏桿菌感染使用抗生素Ampicillin或Ceftriaxone的案例找出Salmonella infection血清型分布情形與抗生素敏感性。分析結果發現serogroup B仍是最多的，serogroup D1次之，所有沙門氏桿菌菌株對Ampicillin、Sulfamethoxazole/Trimethoprim （SMX/TMP）、Ceftriaxone 與Ciprofloxacin的敏感性分別為67.32%、73.86%、96.08%與98.04%。

關鍵字

沙門氏桿菌 ； 敏感性 ； 抗藥性

並列摘要

Background: Salmonella is the most common cause of bacterial enterocolitis among children and infants. About 15- 20% of the patients admitted due to acute enterocolitis were infected with salmonella in our hospital during recent years. Ampicillin has been the first line of empiric treatment for the inpatients with salmonella infection. Antibiotic resistance rate have steadily increased in Taiwan, hence, antibiotic susceptibility is very important to clinicians.Method: To evaluate the epidemiology and antibiotic susceptibility in our hospital, we have collected 143 inpatients with Salmonella infection at our hospital from Jaunary 1, 2007 to December 31, 2009. Antibiotic susceptibility were analyzed for evaluating antibiotic resistance.Result: A total 143 Salmonella isolates were analyzed in this study. Serogroup B has been the most prevalent (37.25%) among all Salmonella isolates, followed by serogroup D1 (35.95%) and serogroup C (20.26%).Discussion: The sensitivity for treating Samonella is 67.32% for ampicillin, 73.86% for sulfamethoxazole/ trimethopim (SMX/TMP), 96.8% for ceftriaxone, and 98.04% for ciprofloxacin. Third generation of cephalosporins and fluoroquinolones remained effective against most of the Salmonella infection during this study period.

並列關鍵字

Salmonella ； susceptibility ； resistance