摘要
心血管疾病造成慢性腎臟病患者極高的死亡率公己是重要的公共健康議題。一般引導心血管疾病的因素，有傳統的與非傳統的因子。但是只用傳統性危險因子無法充份解釋慢性腎臟病病人在心血管疾病的高危險性，甚至會低估心血管疾病在慢性腎臟病病人發生的機率和嚴重度。許多研究陸續發現，在慢性腎臟病患，統性危險因子如氧化壓力會增加心血管疾病，相較於一般健康人群，慢性腎臟病患有明顯偏高的氧化壓力。氧化壓力是活性氧化物生成和抗氧化防禦兩者失衡的結果。對慢性腎臟病患而言，氧化壓力的增加，主要來自於抗氧化物質的缺乏，及氧化物質清除系統的缺陷。此篇文章主要在探考慢血液透析患者氧化壓力增加的各種原因及證據，也會簡述有效改善氧化壓力的策略及方法。
並列摘要
It is well documented that cardiovascular morbidity as well as mortality are increased in patients along with the development of chronic kidney disease (CKD)[1-5]. Traditional risk factors per se are not able to give a satisfactory explanation for this burden in these patients[6-9]. Recently, other non-traditional risk factors, including oxidative stress, have been proposed to participate in the cardiovascular mortality in uremia [10, 11].There is a body of evidence indicating that oxidative stress occurs in patient with CKD. Oxidative stress is defined as the imbalance between prooxidant and antioxidant mechanisms in favor of the former that ultimately leads to oxidation of all basic cell components, i.e. proteins, lipids, DNA, and carbohydrates. This article (1) reviews the evidence and causes for oxidative stress in CKD, (2) briefly discuss the current strategies for ameliorating oxidative stress in these patients.
延伸閱讀
- 陳冬生（2009）。氧化壓力檢測平台之開發與降低血液透析病人氧化壓力之策略〔博士論文，中原大學〕。華藝線上圖書館。https://doi.org/10.6840/cycu200900693
- 許博堯、方基存（2001）。氧化壓力傷害(Oxidant stress)在血液透析病患的治療與應用。腎臟與透析，13(2)，93-96。https://www.airitilibrary.com/Article/Detail?DocID=a0000067-200105-13-2-93-96-a
- Liou, S. Y. (2000). 氧化壓力與血漿析離術. Acta Nephrologica, 14(4), 331-331. https://www.airitilibrary.com/Article/Detail?DocID=10131671-200010-14-4-331-331-o
- 廖國毅、楊芝青（2007）。血液透析與氧化壓力。中華民國血液淨化醫學會雜誌，12(1&2)，21-35。https://doi.org/10.30024/JFBPS.200706.0004
- 李安仁、李惠傑、陳興漢、黃坤崙、蔡政達、王貴勤、馬鴻均（1992）。臨床使用一大氣壓純氧或高壓氧安全性之組織病理評估。Journal of Medical Sciences，12(6)，392-397。https://www.airitilibrary.com/Article/Detail?DocID=10114564-199206-201307030035-201307030035-392-397