Hormone Replacement Therapy and Quality of Life: A Systematic Review

系統性回顧賀爾蒙補充療法是否影響停經婦女的生活品質

李悅源(Yue-Yuan Lee) ； 簡陳榮(Chen-Lung Chien) ； 徐約翰(John Hsu)

《童綜合醫學雜誌》 11卷1期 (2017/06) Pp. 5-9

摘要

Background: Hormone replacement therapy is widely used for controlling menopausal symptoms. Objective: To assess the effects of hormone replacement therapy on the quality of life of postmenopausal women. Search strategy: We searched the following databases for relevant articles published between 2003 and 2014: Cochrane Central Register of Controlled Trials, PubMed, and Google Scholar. Selection criteria: We selected randomized controlled, double-blind trials evaluating hormone replacement therapy versus placebo for postmenopausal women. Hormone therapy included administration of estrogens, with or without progestogens, via the oral route. Main results: Three trials involving 20,561 postmenopausal women were included. None of the studies reported any significant benefit on the quality of life. Authors' conclusions: Although combined hormone replacement therapy is involved in the treatment of menopausal symptoms, there is no evidence that it improves the quality of life.

關鍵字

Hormone replacement therapy ； menopause ； quality of life

並列摘要

賀爾蒙補充療法被廣泛使用於改善停經後婦女的更年期症狀，賀爾蒙治療是否影響停經後女性的生活品質則是受到臨床醫師關注的議題。本文系統性回顧文獻資料庫中，臨床試驗採隨機對照研究，對於停經後女性使用口服雌激素加黃體素與使用安慰劑，兩組生活品質是否達統計學上的差異。目前的結論顯示賀爾蒙補充療法雖然有效改善更年期症狀，但並不能顯著改善停經後婦女的生活品質。

並列關鍵字

賀爾蒙補充療法 ； 停經 ； 生活品質