第二型糖尿病老年患者血清尿酸與代謝參數、腎功能及發炎指標之相關性

Correlation of Serum Uric Acid with Metabolic Parameters, Renal Function, and Inflammatory Markers in Older Adults with Type 2 Diabetes

黃瑞華(Jui-Hua Huang) ； 盧義發(Yi-Fa Lu) ； 陳甫州(Fu-Chou Cheng) ； 李寧遠(Ning-Yuean Lee) ； 蔡麗卿(Leih-Ching Tsai)

《台灣老年醫學暨老年學雜誌》 7卷3期 (2012/08) Pp. 175-193

https://doi.org/10.29461/TGG.201208.0003

摘要

Objective: The present study was to investigate relationships among uric acid, metabolic control, renal function, and inflammatory markers in older adults with type 2 diabetes.Research design and methods: The cross-sectional study was used and included 210 type 2 diabetes patients aged 65 years and above. Clinical variables included anthropometric measurements, blood pressure, and biochemical determinations of blood and urine samples. General linear model was applied to determine the relationships between serum uric acid with metabolic control, and renal function, and inflammatory markers.Results: The high prevalence of hyperuricemia were found in elderly type 2 diabetes patients, in which patients with high triglyceride, central obesity, high body mass index, chronic kidney disease, high serum creatinine, and high blood urea nitrogen had high uric acid levels and hyperuricemia (p＜0.05). For high-sensitivity C-reactive protein (hsCRP) levels, the moderate and high risk of patients revealed higher percentage of hyperuricemia than those of the low risk group (p＜0.05). Patients with higher white blood cell counts showed significantly higher serum uric acid level and percentage of hyperuricemia than those of lower white blood cell counts (p＜0.05). After adjusting confounding factor, triglycerides, waist circumference, body mass index, creatinine, blood urea nitrogen, and hsCRP were significantly higher with increasing quartile of serum uric acid (p＜0.05). In addition, white blood cell counts were marginal higher with increasing quartile of serum uric acid (p=0.056). Glycated hemoglobin and estimated glomerular filtration rate were significantly lower with increase quartile ofserum uric acid (p＜0.05).Conclusions: Serum uric acid was highly associated with metabolic control, nephropathy, and inflammatory markers in elderly type 2 diabetes patients. In addition, serum uric acid may serve as a potential biomarker for blood dyslipidemia, obesity, cardiovascular disease risk, and renal function decline in elderly type 2 diabetes patients. Although elevated serum uric acid may benefit glycemic control, the mechanisms remain unclear.

關鍵字

糖尿病 ； 尿酸 ； 代謝參數 ； 腎功能 ； 發炎

並列摘要

Objective: The present study was to investigate relationships among uric acid, metabolic control, renal function, and inflammatory markers in older adults with type 2 diabetes.Research design and methods: The cross-sectional study was used and included 210 type 2 diabetes patients aged 65 years and above. Clinical variables included anthropometric measurements, blood pressure, and biochemical determinations of blood and urine samples. General linear model was applied to determine the relationships between serum uric acid with metabolic control, and renal function, and inflammatory markers.Results: The high prevalence of hyperuricemia were found in elderly type 2 diabetes patients, in which patients with high triglyceride, central obesity, high body mass index, chronic kidney disease, high serum creatinine, and high blood urea nitrogen had high uric acid levels and hyperuricemia (p＜0.05). For high-sensitivity C-reactive protein (hsCRP) levels, the moderate and high risk of patients revealed higher percentage of hyperuricemia than those of the low risk group (p＜0.05). Patients with higher white blood cell counts showed significantly higher serum uric acid level and percentage of hyperuricemia than those of lower white blood cell counts (p＜0.05). After adjusting confounding factor, triglycerides, waist circumference, body mass index, creatinine, blood urea nitrogen, and hsCRP were significantly higher with increasing quartile of serum uric acid (p＜0.05). In addition, white blood cell counts were marginal higher with increasing quartile of serum uric acid (p=0.056). Glycated hemoglobin and estimated glomerular filtration rate were significantly lower with increase quartile ofserum uric acid (p＜0.05).Conclusions: Serum uric acid was highly associated with metabolic control, nephropathy, and inflammatory markers in elderly type 2 diabetes patients. In addition, serum uric acid may serve as a potential biomarker for blood dyslipidemia, obesity, cardiovascular disease risk, and renal function decline in elderly type 2 diabetes patients. Although elevated serum uric acid may benefit glycemic control, the mechanisms remain unclear.

並列關鍵字

diabetes ； uric acid ； metabolic parameters ； renal function ； inflammatory