Objective: This study aimed to investigate quality of life and the self-reported health status in Taiwanese elderly outpatients. Methods: 311 elderly patients at outpatient clinics of Family Medicine, Geriatrics and Gerontology in National Taiwan University Hospital were recruited. Research subjects were assessed with structured questionnaires including Taiwan WHOQOL, Taiwan IPAQ-Tkcal and Taiwan WONCA-COOPS. Results: Mean age of all participants was 75.52±6.24 years and mean number of diseases was 4.70±1.79. Mean score of Taiwan WHOQOL was 3.52±0.44 and the score relating to general health was the lowest (2.91±0.83). QOL was not associated with age, but significantly associated with the number of diseases, IPAQTkcal and WONCA-COOPS (all p<0.05). In Taiwan WHOQOL, the scores relating to overall QOL and general health were significantly associated with the physical domain and psychological domain of Taiwan WHOQOL. (0.41≦r≦0.50, p<0.01). Conclusion: Quality of life is not associated with aging but is associated with self-reported health status, especially in physical and psychological health. Effective intervention to increase active life expectancy is important in elderly care.