- 期刊
One-Year Variation of Fasting Plasma Glucose is a Strong Predictor of Hip Fracture in Elders with Type 2 Diabetes Mellitus: The Taiwan Diabetes Study
並列摘要
Background: Glucose stability is one of the goals in the management of diabetes. Diabetes is reported to be a risk factor of osteoporosis, an important risk factor of hip fracture. However, epidemiological studies exploring the effect of glucose stability on the risk of hip fracture among type 2 diabetic patients hasn't been done. The present study examined the association between one-year glucose variation as measured by coefficient of variation (CV) of fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) and hip fracture in a large number of type 2 diabetes patients followed for an average of 7.22 years. Methods: We conducted a retrospective cohort study on 13,730 type 2 diabetes elders who participated in the National Diabetes Case Management Program in Taiwan. One-year variation of HbA1c and FPG at baseline and hip fracture events over the 8-9 years was analyzed. Results: There were a total of 933 incident cases of hip fracture. Patients were grouped in tertiles of FPG-CV and HbA1c-CV. The incidence rates for FPG-CV were 7.55, 9.80, and 10.87 per 1000 person years and for HbA1c-CV were 8.71, 9.41, and 10.12 per 1000 person years in the groups of 1st , 2nd, and 3rd tertile, respectively. After adjusting for age, gender, duration of diabetes, type of treatment, smoking, hypertension, hyperlipidemia, FPG-M, HbA1C, and complications, FPG-CV was independently associated with hip fracture, but HbA1c-CV was not. The hazard ratios of hip fracture for 2nd, 3rd versus 1st tertile of FPG-CV were 1.19 (1.01-1.41), and 1.23 (1.04-1.46), respectively. Conclusion: Patients categorized as FPG variation greater than 17.62% or more exhibited an increased risk of hip fracture, confirming a linear relationship. One-year variation of FPG was a strong predictor of hip fracture in type 2 diabetic patients. Our study findings suggest that glucose variation may become a measure in clinical practice for the goal in the management of these patients.
延伸閱讀
- Chen, Y. C., Li, T. C., Lin, C. C., Liu, C. S., & Yang, S. Y. (2014). One-Year Variation of Fasting Plasma Glucose is a Strong Predictor of Chronic Obstructive Pulmonary Disease in Elders with Type 2 Diabetes Mellitus: The Taiwan Diabetes Study. 台灣老年醫學暨老年學雜誌, 9(2), 39-39(2). https://www.airitilibrary.com/Article/Detail?DocID=20719833-201405-201502020050-201502020050-39-39(2)
- Yu, K., Ke, M. Y., Li, W. H., Zhang, S. Q., & Fang, X. C. (2013). The Impact of Soluble Dietary Fibre on Gastric Emptying, Postprandial Blood Glucose and Insulin in Patients with Type 2 Diabetes. Asia Pacific Journal of Clinical Nutrition, (), 10-18. https://doi.org/10.6133/apjcn.2014.23.2.01
- Yu, K., Ke, M. Y., Li, W. H., Zhang, S. Q., & Fang, X. C. (2014). The Impact of Soluble Dietary Fibre on Gastric Emptying, Postprandial Blood Glucose and Insulin in Patients with Type 2 Diabetes. Asia Pacific Journal of Clinical Nutrition, 23(2), 210-218. https://doi.org/10.6133/apjcn.2014.23.2.01
- Cheng, Y. F., & Pei, D. (2023). The Relationships between Fasting Plasma Glucose and Insulin Resistance, Glucose Effectiveness, First- And Second-Phase Insulin Secretion in Elderly Lean Subjects with the Same Age and Body Mass Index. Formosan Journal of Endocrinology and Metabolism, 14(1), 17-25. https://doi.org/10.6856/FJEM.202306_14(1).0003
- Chung, H. F., Hsu, C. C., Mamun, A. A., Long, K. Z., Huang, Y. F., Shin, S. J., Hwang, S. J., & Huang, M. C. (2018). Dietary patterns, dietary biomarkers, and kidney disease in patients with type 2 diabetes: a repeated-measure study in Taiwan. Asia Pacific Journal of Clinical Nutrition, 27(2), 366-374. https://doi.org/10.6133/apjcn.042017.15