- 期刊
High Uric Acid Correlated with High Bone Mineral Density in Older Adults
並列摘要
Objectives: The effect of uric acid of on bone mineral density was not consistent in previous study. The purpose of the study was to examine the relationship between serum uric acid and bone mineral density in Chinese elders. Methods: A total of 1,382 older adults aged 65 years and over was recruited in a community-based cross-sectional study in Taichung City, Taiwan from 2010 to 2012. Among them, 833 older adults who completed serum biomarker examination and dual energy X-ray absorptiometry (DXA) examination were enrolled in this study. Bone mineral density is measured by DXA (GE-LUNAR DPX PRO, Lunar Corporation, Madison, WI, USA) for central sites (total hip, lumbar spine, femoral neck, trochanter, and Ward’s triangle). Serum uric acid concentration was analyzed by a biochemical autoanalyzer and high uric acid was defined as either having gout/hyperuricemia history or uric acid ＞6 mg/dl in women and ＞7 mg/dl in men (402 elders as normal uric acid and 431 elders as high uric acid). The information of weight, body mass index (BMI), waist, estimated glomerular filtration rate (eGFR), blood pressure, health behaviors, and comorbidities were measured. Results: Elders with high uric acid had higher level of weight, BMI, waist circumference, and eGFR, and higher proportion of hypertension, gout, and hyperuricemia than those with normal uric acid. Elders with high uric acid had higher bone density in total body and femoral neck, after adjustment of age, sex, BMI, eGFR, blood pressure, medication for uric acid, and comorbidity of hypertension, hyperuricemia, and gout. The odd ratio of osteopenia was 0.70 in elders with high uric acid compared with those with normal uric acid (p＜0.05) after adjustment of age, sex, BMI, eGFR, and blood pressure. However, after comorbidities was added into model, the effect of uric acid on bone density was disappear. Conclusion: Our study demonstrates that higher uric acid is correlated with higher bone mineral density, but the effect of uric acid on osteoporosis is not observed. The longitudinal effect of uric acid on bone mineral density should be studied in future.
延伸閱讀
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