Q fever is a worldwide zoonotic infectious disease caused by Coxiella burnetii, a Gram-negative obligate intracellular bacterium. The major animal reservoirs of Coxiella burnetii are goats, sheep, and cattle. Humans are usually infected by aerosols contaminated with Coxiella burnetii excreted by an infected animal through fetal products, milk, urine and feces. Patients with acute Q fever commonly present with acute febrile illness with non-specific symptoms and signs, such as influenza-like illness, increased transaminases, thrombocytopenia, or pneumonia. It is also one of the most commonly neglected infectious diseases in tropical regions. We herein present the case of a 93-year-old female with fever of unknown origin later diagnosed to be acute Q fever infection.