- 期刊
- OpenAccess
The Genetic Role of Cyclooxygenase 2 in Ureter Cancer in Taiwan
並列摘要
The association between cyclooxygenase 2 (Cox-2) and ureter cancer has never been investigated in the past. In this study, the association of Cox-2 genotypic polymorphisms with ureter cancer was examined to specifically address this issue. Fifty-six ureter cancer patients and 436 non-cancer controls recruited from the China Medical Hospital in central Taiwan were genotyped and analyzed. Up to six polymorphic variants of Cox-2, including G-1195A, G-765C, T+8473C, intron 1, 5, and 6, were investigated in our study to analyze the association of the genotypes with susceptibility to ureter cancer. At first, no significant difference in the distribution between the ureter cancer and control groups was found in each of the polymorphism site investigated. However, our analysis of the joint effect for Cox-2 G-765C and intron 6 showed that individuals with GC at G-765C and AG+AA at intron 6 presented a higher potential for developing ureter cancer than the other groups. Since there was no obvious association between Cox-2 genotypes and ureter cancer stage or grade, our findings suggest that the C allele of Cox-2 G-765C together with the A allele of intron 6 may be responsible for ureter carcinogenesis and may be useful in the early detection and prediction of ureter cancer.
延伸閱讀
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