Adjuvant Effects of Di-(2-Ethylhexyl) Phthalate on the Inflammatory Process in Glucose Homeostatic Organs in Mice Fed Fat or Carbohydrate Diet

Nisubire Désiré ； Qiang Zeng ； Xu Yang

《Adaptive Medicine》 6卷4期 (2014/12) Pp. 178-184

https://doi.org/10.4247/AM.2014.ABE082

並列摘要

We evaluate the proinflammatory effects of di-(2-ethylhexyl) phthalate (DEHP) in white adipose tissue (WAT), liver, and pancreas of mice fed high-fat (HFD) or high-carbohydrate diets (HCD), and we determine the ability of vitamin E to suppress these deleterious effects. Mice were treated with 500 mg/kg body weight DEHP while receiving an HFD or HCD. After 4 weeks, the mice received a daily oral dose of vitamin E. Ten weeks later, the mice were sacrificed and concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and interferon (IFN)-γ were measured using enzyme-linked immunosorbent assays. HFD-fed mice showed increased cytokine levels in WAT and liver, while HCD-fed mice showed increased cytokine concentrations in the liver and pancreas following DEHP administration. Vitamin E decreased the levels of proinflammatory cytokines in HFD-fed mice, but increased their levels in WAT and the liver in HCD-fed mice. Vitamin E did not affect cytokine levels in the pancreas.

並列關鍵字

di-(2-ethylhexyl) phthalate ； diet ； homeostatic organs ； proinflammatory cytokines ； vitamin E