Muscle Derived Stem Cells and Tissue Engineering for Urological Regeneration

Shing-Hwa Lu ； Alex T. L. Lin

《Adaptive Medicine》 9卷4期 (2017/12) Pp. 153-159

https://doi.org/10.4247/AM.2017.ABH189

摘要

Human multipotent stem cells might be ideal cells for tissue regeneration. Muscle-derived stem cells (MDSC) would be a better choice to do research as it can avoid the ethical issues associated with embryonic stem cells (ESCs). In addition, self-transplantation of MDSC also provides benefit for clinical application. Human MDSC have been successfully isolated using modified preplating technique (MPT). These cells have also been purified using immunoselective method. These purified cells were proven to have the ability of differentiation. Laboratory data showed that by changing the microenvironment of the cells using different proportion of differentiating medium and different kinds of genes and growth factors would successfully differentiate these purified cells into smooth muscle cells, skeletal muscle, adipocytes, osteocytes, chondrocyte and neurogenic cells. These results proved that multipotent stem cells from human skeletal muscle tissue have been successfully isolated. Tissue engineering in Urology may become a more considered approach from idealistic claims and predictions. The approaches of tissue engineering include the management of specific cell such as MDSCs, and management of natural and synthetic biomaterials. In the near future, cell transplantation of tissue reconstructive engineering using human MDSCs (hMDSCs) would offer further benefits to people for bladder reconstitution, treatment of stress urinary incontinence (SUI) and erectile dysfunction (ED).

關鍵字

muscle ； regeneration ； stem cell ； tissue engineering