Roles of Lactate and Corticosterone on Testosterone Biosynthesis in Leydig Cells

Chih-Chieh Chen ； Paulus S. Wang

《Adaptive Medicine》 10卷2期 (2018/06) Pp. 64-68

https://doi.org/10.4247/AM.2018.ABI201

摘要

Previous studies indicated that corticosterone and lactate in circulation were fluctuated during the exercise training. Moreover, the unbalanced ratio of corticosterone to testosterone (C/T ratio) was used as a powerful biomarker which can reflect the athletes' physiological condition under overtraining/inappropriate situation as the suggestions in the previous studies. It has been reported that corticosterone played a suppression role in testosterone release in vitro and in vivo. However, lactate has been evidenced that it increased testosterone release by the cyclic adenosine monophosphate (cAMP) pathway in vitro and in vivo. Therefore, those studies point out that the lactate and corticosterone played adverse roles in altering testosterone level. Furthermore, the combination effects of corticosterone and lactate on testosterone biosynthesis still remain unclear. Thus, in this article, we discussed the issues about (1) the relationship between overtraining syndrome and exercise performance, (2) effects of lactate and corticosterone on testosterone secretion in rat Leydig cells, and (3) other potential mechanisms of corticosterone or lactate on testosterone synthesis in Leydig cells. According to the evidence of previous studies, we summarized that corticosterone played a dominant role in suppression of the lactate-stimulated testosterone secretion from Leydig cells by decreasing luteinizing hormone receptor (LHR) deglycosylation as well as intracellular cAMP level.

關鍵字

Corticosterone ； lactate ； Leydig cells ； LHR ； testosterone