Subacute Oral Toxicity Evaluation of A. Camphorata Mycelium in ICR Mice

Wen-Ching Huang ； Chien-Chao Chiu ； Mon-Chien Lee ； Chi-Chang Huang

《Adaptive Medicine》 10卷3期 (2018/09) Pp. 79-89

https://doi.org/10.4247/AM.2018.ABI207

摘要

Antrodia camphorata is endemic fungus in Taiwan and it is applied to treat abdominal pain, hypertension, metabolic diseases and hepatocellular carcinoma in folk medicine. The active ingredients and mechanisms were widely studied for new drug and health food development. Subacute oral toxicity studies of A. camphorata extracts were performed to evaluate its safety with ICR mice. The three different concentrations of A. camphorata (500, 1000 and 1667 mg/kg/day) were given orally to 3 groups of mice (10 mice/dose) for 28 consecutive days. All animals survived to the end of the study, and there were no significant differences in growth curve, dietary, behaviors, and ophthalmology among the control and treatment groups. The serum biochemical parameters also showed in normal and reasonable range. Haematological and biochemical parameters also revealed no toxic effects of the extract on mice. The A. camphorata supplementation also didn't affect the neuromuscular functions and the examination in histopathology was normal. In current study, we elucidated the A. camphorata could be safe materials with 1667 mg/kg NOAEL for further health promotions regarding to indicated bioactivities.

關鍵字

biochemistry ； neuromuscular functions ； NOAEL ； safety ； subacute toxicity