- 期刊
- OpenAccess
Contrasting Effects of the Neuropeptides Substance P, Somatostatin, and Neuropeptide Y on the Methamphetamine-Induced Production of Striatal Nitric Oxide in Mice
並列摘要
Several laboratories have shown that methamphetamine (METH) neurotoxicity is associated with increases of nitric oxide (NO) production in striatal tissue and blockade of NO production protects from METH. Because substance P modulates NO production, we tested the hypothesis that intrinsic striatal neuropeptides such as somatostatin and neuropeptide Y (NPY) modulate striatal NO production in the presence of METH. To that end, METH (30 mg/kg, IP) was injected into adult male mice alone or in combination with pharmacological agonists or antagonists of the neurokinin-1 (substance P), somatostatin or NPY receptors and 3-nitrotyrosine (an indirect index of NO production) was assessed utilizing HPLC or a histological method. Pre-treatment with the systemic neurokinin-1 receptor antagonist WIN-51,708 significantly attenuated the METH-induced production of striatal 3-NT measured at two hours post-METH. Conversely, intrastriatal injection of NPY1 or 2 receptor agonists inhibited the METH-induced production of striatal 3-NT. Similarly, intrastriatal infusion of the somatostatin receptor agonist octreotide attenuated the METH-induced striatal production of 3-NT. Taken together, our results suggest the hypothesis that the neuropeptide substance P is pro-damage while the neuropeptides somatostatin and NPY are anti-damage in the presence of METH by targeting the production of NO.
延伸閱讀
- Vechoropoulos, M., Shalom, M. I., Shaklai, S., Sack, J., Stern, N., & Tordjman, K. M. (2014). The Proatherogenic Effect of Chronic Nitric Oxide Synthesis Inhibition in ApoE-Null Mice Is Dependent on the Presence of PPARα. PPAR Research, 2014(), 5-14. https://doi.org/10.1155/2014/124583
- Kita, M., Watanabe, T., Suzuki, T., Sato, I., Hossain, M. M., & Kobayashi, H. (2013). Effects of Repeated Administration of Inhaled Anesthetics on Anesthesia, Brain Acetylcholinesterase, Muscarinic Receptors and Dopaminergic Receptors in Mice. Advances in Biomedical Engineering Research, 1(2), 24-32. https://www.airitilibrary.com/Article/Detail?DocID=P20150529002-201306-201509240012-201509240012-24-32
- Lee, C. M. (1977). Biochemical and electrophysiological studies on the effects of morphine on dopaminergic neurotransmission in the caudate nucleus ofrats [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200005167
- Dar, M. S. (2013). Involvement of Mouse Cerebellar Neuronal Nitric Oxide Synthase (nNOS) System in the Functional Interaction and Cross-Tolerance between Nicotine and Ethanol. Journal of Drug and Alcohol Research, (2), 90-97. https://doi.org/10.4303/jdar/235788
- Yang, S. N., Hsieh, W. Y., Liu, D. D., Tsai, L. M., Tung, C. S., & Wu, J. N. (1998). The Involvement of Nitric Oxide in Synergistic Neuronal Damage Induced by β-amyloid Peptide and Glutamate in Primary Rat Cortical Neurons. The Chinese Journal of Physiology, 41(3), 175-179. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199809-41-3-175-179-a