Association Study of ＂FYN＂ Gene Polymorphism and Methamphetamine Use Disorder

Shinji Sakamoto ； Yuko Okahisa ； Manabu Takaki ； Yutaka Mizuki ； Masafumi Kodama ； Kumi Aoyama-Uehara ； Mujun Won ； Naoki Kondo ； Nobuya Naruse ； Ichiro Sora ； Nakao Iwata ； Masaomi Iyo ； Norio Ozaki ； Hiroshi Ujike ； Yosuke Uchitomi

《Journal of Drug and Alcohol Research》 2期 (2013/11) Pp. 98-103

https://doi.org/10.4303/jdar/235790

並列摘要

Fyn kinase belongs to the Src family of tyrosine kinases and phosphorylates NMDA receptor subunits. The Fyn kinase gene, ＂FYN＂, has been considered to be involved in the pathophysiologies of neuropsychiatric diseases. We examined three polymorphisms, rs706895, rs3730353, and rs6916861, of the ＂FYN＂ gene in 250 patients with methamphetamine use disorder and 275 controls. There were no significant differences between the patients and controls in genotype or allele distribution. In haplotype association analyses, the C-T haplotype at rs3730353-rs6916861 showed a significant association with methamphetamine use disorder. We also analyzed the clinical phenotypes of methamphetamine use disorder. Rs3730353 and rs6916861 showed a significant association with age at first consumption in genotype and allele distributions, and multiple-substance abuse status in the genotype distribution. The present study suggests that genetic variation of the ＂FYN＂ gene may be related to the severity of methamphetamine use disorder in a Japanese population.

並列關鍵字

methamphetamine ； FYN ； NMDA ； clinical phenotype ； haplotype